![]() The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have read the journal's policy and have the following conflicts. 511066 from the National Health and Medical Research Council of Australia. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.įunding: This work was supported by Project Grant no. Received: FebruAccepted: MaPublished: April 26, 2012Ĭopyright: © 2012 Harms et al. PLoS ONE 7(4):Įditor: Kenji Hashimoto, Chiba University Center for Forensic Mental Health, Japan However, impairments in perseverative responding in DVD-deficient mice may indicate that these animals have specific alterations in systems governing compulsive or reward-seeking behaviour.Ĭitation: Harms LR, Turner KM, Eyles DW, Young JW, McGrath JJ, Burne THJ (2012) Attentional Processing in C57BL/6J Mice Exposed to Developmental Vitamin D Deficiency. DVD-deficient mice exhibited no major impairments in any of the cognitive domains tested. DVD deficiency did not affect the acquisition or retention of cued fear conditioning, nor did it affect the expression of latent inhibition using a fear conditioning paradigm. In the 5C-CPT DVD-deficient male mice exhibited an impairment in inhibiting repetitive responses by making more perseverative responses, with no changes in premature or false alarm responding. DVD deficiency was not associated with altered attentional performance on the 5C-SRT. The adult offspring were tested on a range of cognitive behavioural tests, including the five-choice serial reaction task (5C-SRT) and five-choice continuous performance test (5C-CPT), as well as latent inhibition using a fear conditioning paradigm. After six weeks on the diet, vitamin D-deficient and control females were mated with vitamin D-normal males and upon birth of the pups, all dams were returned to a diet containing vitamin D. ![]() ![]() DVD deficiency was established by feeding female C57BL/6J mice a vitamin D-deficient diet from four weeks of age. The aim of this study was to determine the effect of DVD deficiency on a range of cognitive tasks assessing attentional processing in C57BL/6J mice. ![]() DVD deficiency in mice is associated with altered behaviour, however there has been no detailed investigation of cognitive behaviours in DVD-deficient mice. Epidemiological evidence suggests that Developmental Vitamin D (DVD) deficiency is associated with an increased risk of schizophrenia. ![]()
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